Platelet amyloid precursor protein processing: A bio-marker for Alzheimer's disease
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چکیده
منابع مشابه
Platelet amyloid precursor protein processing: a bio-marker for Alzheimer's disease.
The amyloid precursor protein (APP) in brain is processed either by an amyloidogenic pathway by beta-secretase and gamma-secretase to yield Abeta (beta-amyloid 4 kDa) peptide or by alpha-secretase within the beta-amyloid domain to yield non-amyloidogenic products. We have studied blood platelet levels of a 22-kDa fragment containing the Abeta (beta-amyloid 4 kDa) peptide, beta-secretase (BACE1)...
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The proteolytic processing of the amyloidprotein precursor plays a key role in the development of Alzheimer’s disease. Cleavage of the amyloidprotein precursor may occur via two pathways, both of which involve the action of proteases called secretases. One pathway, involving and -secretase, liberates amyloidprotein, a protein associated with the neurodegeneration seen in Alzheimer’s disease. Th...
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ژورنال
عنوان ژورنال: Journal of the Neurological Sciences
سال: 2006
ISSN: 0022-510X
DOI: 10.1016/j.jns.2005.09.002